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实验室研究方向：

t cells play essential roles in immune response. we are studying t cells with two directions:

1. functional genomics in primary t cells

we are applying genome-wide crispr/cas9 screen in primary t cell in vivo to answer fundamental questions in t cell biology, including development, activation, proliferation and differentiation, as well as t cell fitness (e.g. exhaustion) in tumor microenvironment. identified novel genes and regulatory circuits have been used to design novel therapies for diseases.

2. mechanisms of metabolic regulation of t cells

metabolic reprogramming is a hallmark of t cell activation, but how metabolic pathways regulate t cell function remains poorly understood. we are using mouse models with gain- and loss-of-function of key metabolic enzymes to decipher metabolic regulation t cell, and try to target metabolism to treat immune-related diseases.

近期代表性成果如下，

1.min peng, na yin, ming o. li. szt2 dictates gator control of mtorc1 signaling.nature. 2017 mar 16;543(7645):433-437.

2.min peng*, na yin*, sagar chhangawala, ke xu, christina s. leslie, ming o. li. aerobic glycolysis promotes t helper 1 cell differentiation through an epigenetic mechanism.science, 2016 oct 28; 354(6311): 481-484.*equal contribution.

preview inscience, 2016 oct 28; 354(6311): 419-420.“warburg meets epigenetics”.

preview indev cell, 2016 november 7;39: 286-287.“metabolic control of cellular differentiation”.

preview incell metab, 2016 november 8; 24: 651-652.“metabolic signaling drives ifn-g”.

3.min peng, na yin, ming o. li. sestrins function as guanine nucleotide dissociation inhibitors for rag gtpases to control mtorc1 signaling.cell. 2014 sep 25; 159(1): 122-33.

highlighted innat rev mol cell biol, 2014; 15: 701,“a rag dissociation inhibitor”.

博士后招聘1-2名：

应聘条件：具有免疫学、分子和细胞生物学相关专业博士学位，获得博士学位1年以内；近期以第一作者身份在国际知名学术期刊发表研究论文，符合清华大学博士后入站标准，年龄小于35周岁；热爱科研工作，责任心强，具备团队合作精神；具备较好的英语沟通、阅读和写作能力。

岗位待遇：在清华大学校定博士后工资待遇基础上，根据工作经验和能力可以享受具有国际竞争力的年薪式津贴。符合条件者，支持申请国家“博新计划”、清华“水木学者”、以及生命科学联合中心博士后奖学金支持计划。

申请方式：将简历（包括学历和论文发表情况）、研究自述（研究兴趣、成果以及未来职业规划）、及2-3名推荐人的联系方式发至：；主题标明“姓名+应聘博士后+高校人才网“。

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